Due to anatomic constraints and a high degree of radiosensitivity, radiotherapy is the main treatment for NPC, and the TNM staging system is the most reliable method for devising clinical treatment strategies and predicting prognosis 2.
Nasopharyngeal carcinoma (NPC) is a cancer with an unbalanced geographical distribution, with an age-standardised incidence rate of 20–50 per 100,000 males in south China but only 0♵ per 100,000 in predominantly white populations of European origin 1. In conclusion, diabetes does not appear to be a prognostic factor in NPC patients treated with IMRT, and attention should be paid to hyperglycemia-associated hyperlipaemia.ĭata on global cancer revealed an estimated 84,400 new cases of nasopharyngeal carcinoma (NPC) and 51,600 deaths in 2011 1. Multivariate analysis did not established diabetes as poor prognostic factors in NPC patients treated with IMRT ( P = 0.332 for DFS, P = 0.944 for OS, P = 0.977 for LRRFS, P = 0.157 for DMFS), however, triglycerides and low density lipoprotein cholesterol were independent prognostic factors. The 4-year disease-free survival (DFS), overall survival (OS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) rates were 77.1% vs. We retrospectively reviewed medical records of 1489 patients with non-metastatic, histologically-proven NPC treated using IMRT. The prognostic value of diabetes remains unknown in nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT).
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